Abstract

Antibiotics are a necessary medication used to treat bacterial diseases like meningitis and pneumonia. Around the world, gentamicin is a commonly used antibiotic. Gentamicin sulphate's effects on the uterus and ovaries of non-pregnant Sprague-Dawley rats were the focus of the investigation. In this study, twenty-four female rats were split up into A-D groups of six. Groups A, B, C, and D were administered intramuscular injections of 0, 20, 40, and 80 mg/kg for a duration of four weeks. The animals were euthanized when the study was over, and blood was taken for hormonal examination and the organs were removed for histology and oxidative stress measurements. Across all treatment groups, gentamicin markedly raised MDA levels while suppressing SOD and CAT levels. Progesterone, LH, and FSH levels were also decreased. Both the uteri and the ovaries displayed vascular congestion in the ovaries and moderate to severe damage in the uterine lumen. In non-pregnant Sprague-Dawley rats, gentamicin use can negatively impact the histoarchitecture of the uterus and ovaries in addition to altering hormone levels and oxidative stress indicators.

Copyright of the paper named above is hereby assigned and transferred to the Nigerian Journal of Applied Science and Innovative Technology published by College of Engineering, Bells University of Technology, Nigeria.